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Article

CNS Endothelial Cell Activation Emerges as a Driver of CAR T Cell–Associated Neurotoxicity

1 Dec 2017

Abstract excerpt

Abstract Summary: Central nervous system (CNS) toxicity associated with chimeric antigen receptor–based therapeutics has emerged as a significant cause of morbidity and mortality, and insights into the pathophysiology of this syndrome have been lacking. A new study provides evidence that cytokine-induced CNS endothelial cell activation leading to disruption of the blood–brain barrier plays an early and critical...

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Identifiers

PMID: 29208775
DOI: 10.1158/2159-8290.cd-17-1084

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