Back to search

Article

Expansion of endogenous T cells in CSF of pediatric CNS tumor patients undergoing locoregional delivery of IL13R⍺2-targeting CAR T cells: an interim analysis

2023-10-23

Abstract excerpt

<title>Abstract</title> <p>Outcomes for pediatric brain tumor patients remain poor, and there is optimism that chimeric antigen receptor (CAR) T cell therapy can improve prognosis. Here, we present interim results from the first six pediatric patients treated on an ongoing phase I clinical trial (NCT04510051) of IL13BBζ-CAR T cells delivered weekly into the lateral cerebral ventricles, identifying clonal expansio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c04ba7df-5690-5fd5-9df6-95bfad3173c2
DOI
10.21203/rs.3.rs-3454977/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Expansion of endogenous T cells in CSF of pediatric CNS tumor patients undergoing locoregional delivery of IL13R⍺2-targeting CAR T cells: an interim analysisDOI 10.21203/rs.3.rs-3454977/v1
Evolving CAR T-Cell Therapy to Overcome the Barriers in Treating Pediatric Central Nervous System TumorsSemantic proximity
Efficacy and Safety of Chimeric Antigen Receptor T-Cell Therapy in Children, Adolescents, and Young Adults with Relapsed or Refractory Solid Tumors: A Systematic Review and Meta-AnalysisSemantic proximity
CD19-directed CAR T-cell therapy for treatment of primary CNS lymphomaSemantic proximity
Molecular monitoring of T-cell kinetics and migration in severe neurotoxicity after real-world CD19-specific chimeric antigen receptor T cell therapySemantic proximity
Chimeric Antigen Receptor‐T Cell TherapySemantic proximity
Current Role and Future Potential of CSF ctDNA for the Diagnosis and Clinical Management of Pediatric Central Nervous System Tumors.Semantic proximity
COVID-19 in pediatric cancer: where are the brain tumors?Semantic proximity
IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomasSemantic proximity
Baseline WT1-specific immunity and immune responses to WT1-targeted immunotherapy in pediatric patients with malignant solid tumors at high risk for relapse: results from a biomarker-driven multicenter translational phase II clinical trialSemantic proximity
Phase I study of repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab in patients with newly diagnosed, MGMT-unmethylated glioblastomaSemantic proximity
Immune checkpoint inhibitors in pediatric central nervous system tumors: biology, clinical experience, and translational pathways to precision immunotherapy.Semantic proximity
Immuno-oncologic profiling of pediatric CNS tumors reveals major clinical significance of the tumor immune microenvironmentSemantic proximity
Select a neighboring publication to make it the new centre.