Article

GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology

2023-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy (ML/DHRD) is an age-related macular degeneration (AMD)-like retinal dystrophy caused by an autosomal dominant R345W mutation in the secreted glycoprotein, fibulin-3 (F3). To identify new small molecules that reduce F3 production from retinal pigmented epithelium (RPE) cells, we knocked-in a luminescent peptide tag (HiBiT) into the endogenous...

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Literature Corpus work: 0959b9a5-790c-576b-b51f-0a04d2da7fb1
DOI: 10.1101/2023.12.14.571757

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