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Article

A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion.

Journal of biomolecular screening - 1 Jul 2013

Hulleman John D, Brown Steven J, Rosen Hugh, Kelly Jeffery W

Abstract excerpt

An R345W mutation in fibulin-3 causes its inefficient secretion, increased intracellular steady-state levels, and the macular dystrophy, Malattia Leventinese (ML), a disease similar to age-related macular degeneration. It is unknown whether R345W causes ML through increased intracellular levels, by the secretion of a potentially aggregation-prone protein, or both. To identify small molecules that alter the...

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Identifiers

PMID: 23230284
DOI: 10.1177/1087057112469405
PMCID: PMC4435789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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