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Article

Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2020

Daniel Steffi, Renwick Marian, Chau Viet Q, Datta Shyamtanu, Maddineni Prabhavathi, Zode Gulab, Wade Emma M, Robertson Stephen P, Petroll W Matthew, Hulleman John D

Abstract excerpt

Fibulin-3 (F3) is an extracellular matrix glycoprotein found in basement membranes across the body. An autosomal dominant R345W mutation in F3 causes a macular dystrophy resembling dry age-related macular degeneration (AMD), whereas genetic removal of wild-type (WT) F3 protects mice from sub-retinal pigment epithelium (RPE) deposit formation. These observations suggest that F3 is a protein which can regulate...

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Source

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Identifiers

PMID: 32964303
DOI: 10.1007/s00109-020-01974-z
PMCID: PMC7606609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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