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Article

Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.

Nature communications - 15 Dec 2021

Sharma Ruchi, George Aman, Nimmagadda Malika, Ortolan Davide, Karla Barbosa-Sabanero, Qureshy Zoya, Bose Devika, Dejene Roba, Liang Genqing, Wan Qin, Chang Justin, Jha Balendu Shekhar, Memon Omar, Miyagishima Kiyoharu Joshua, Rising Aaron, Lal Madhu, Hanson Eric, King Rebecca, Campos Mercedes Maria, Ferrer Marc, Amaral Juan, McGaughey David, Bharti Kapil

Abstract excerpt

Age-related Macular Degeneration (AMD), a blinding eye disease, is characterized by pathological protein- and lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE) and atrophy of the RPE monolayer in advanced disease stages - leading to photoreceptor cell death and vision loss. Currently, there are no drugs that stop drusen formation or RPE atrophy in AMD. Here we provide an iPSC-RPE AMD...

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Share to Complement Factor H
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

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Source

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Identifiers

PMID: 34911940
DOI: 10.1038/s41467-021-27488-x
PMCID: PMC8674335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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