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A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

1 Oct 2019

Abstract excerpt

Id helix-loop-helix (HLH) proteins (Id1-4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during development to inhibit differentiation, but they become re-expressed in adult tissues in diseases of the vasculature and cancer. We show that the genetic loss of Id1/Id3 reduces ocular...

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PMID: 31577956
DOI: 10.1016/j.celrep.2019.08.073

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