Article

Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma

2018-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulation of the complement system is implicated in neurodegeneration, including human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by local complement upregulation and activation, but whether targeting this early innate immune response could have therapeutic benefit remains undefined. Because complement signals through three pathways that intersect at compleme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2820260a-99c2-53e6-b9d0-0fed21344d2a
DOI: 10.1101/369181

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucomaDOI 10.1101/369181Read

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse GlaucomaSemantic proximity Read

Complement Component 1Q (C1Q) Upregulation in Retina of Murine, Primate, and Human Glaucomatous EyesSemantic proximity Read

Intracellular complement C3/C3aR/STAT3 pathway inactivation attenuates retinal degeneration in miceSemantic proximity Read

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucomaSemantic proximity Read

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucomaSemantic proximity Read

A novel role of complement in retinal degeneration.Semantic proximity Read

Truncated Complement Factor H Y402 Gene Therapy Cures C3 GlomerulonephritisSemantic proximity Read

Complement regulation in the eye: implications for age-related macular degenerationSemantic proximity Read

Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between JAK/STAT signaling and innate immune responses in the zebrafish retinaSemantic proximity Read

Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injurySemantic proximity Read

Complement C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosaSemantic proximity Read

Anaphylatoxin Receptor C3AR1 Promotesoptic Nerve Degeneration in DBA/2J MiceSemantic proximity Read