Article

Genetic removal of Nlrp3 protects against sporadic and R345W Efemp1-induced basal laminar deposit formation

2024-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Chronic, unresolved inflammation has long been speculated to serve as an initiating and propagating factor in numerous neurodegenerative diseases, including a leading cause of irreversible blindness in the elderly, age-related macular degeneration (AMD). Intracellular multiprotein complexes called inflammasomes in combination with activated caspases facilitate production of pro-inflammatory cyto...

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Literature Corpus work: 09fdea73-e4df-55b6-8a81-4bf79b6d8a79
DOI: 10.1101/2024.10.14.618289

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