Article

Cancer cells impede T cell early activation and drive immune evasion by transferring Tmem176b

2025-07-07

Abstract excerpt

<title>Abstract</title> <p>Despite its remarkable clinical success in human cancer treatment, immune checkpoint blockade is effective only in a minority of patients. One major obstacle is tumor-driven impairment of T cell priming and early activation, however, the underlying mechanism remains elusive. Here we identify TMEM176B-positive exosomes specifically secreted by cancer cells in plasma of cancer patients ra...

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Identifiers and source

Literature Corpus work: 02699704-1c8c-5b5c-a7c7-aaaec40f240b
DOI: 10.21203/rs.3.rs-6199894/v1

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