Article
Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment.
PloS one - 1 Jan 2014
Cohen Jarish N, Tewalt Eric F, Rouhani Sherin J, Buonomo Erica L, Bruce Amber N, Xu Xiaojiang, Bekiranov Stefan, Fu Yang-Xin, Engelhard Victor H
Abstract excerpt
Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase, and induce deletion of specific CD8 T cells via Programmed Death Ligand-1 (PD-L1). Here, we demonstrate that high-level expression of peripheral tissue antigens and...
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