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Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes

1 Dec 2018

Abstract excerpt

Enlargement of the lymphatic vascular network in tumor-draining lymph nodes (LNs) often precedes LN metastasis, likely providing a lymphovascular niche for tumor cells. We investigated morphological and molecular changes associated with the lymphatic remodeling process, using the 4T1 breast cancer and B16F10 melanoma models. Lymphatic expansion in tumor-draining LNs is mediated by sprouting and proliferation of...

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PMID: 30590031
DOI: 10.1016/j.celrep.2018.12.002

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