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PD-L1 promotes tumor metastasis by regulating the infiltration of FGFBP2(+)Tm cells in colorectal cancer

2024-05-09

Abstract excerpt

<title>Abstract</title> <p>Tumor infiltrating lymphocytes largely determined tumorigenesis and progression. We found PD-L1 can inhibit the infiltration of memory T cells in vivo and in vitro by reducing the secretion of CXCL9,CXCL10 in colorectal cancer. Clinically, patients with high PD-L1 expression had few memory T cells infiltration, resulting in a higher incidence of tumor metastasis. Furthermore, single-cel...

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Literature Corpus work
bcd1e814-e8cb-5b34-abf9-74d8340cbe6f
DOI
10.21203/rs.3.rs-4264499/v1
Open publication

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