Article

Investigation of CMA Substrate Interactions with Hsc70 Reveals Potential Auxiliary Binding Sites

2025-01-30

Abstract excerpt

Chaperone-mediated autophagy (CMA) is a selective lysosomal degradation pathway crucial for cellular homeostasis. Its dysfunction is linked to cancer and neurodegenerative disorders. Hsc70 mediates CMA selectivity by recognizing proteins with ‘KFERQ-type’ sequences, but the structural basis for substrate recognition and the substrate-binding mechanism of Hsc70 remain unclear. This study integrates literature, bioi...

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Literature Corpus work: 092f77f5-c663-5cda-ae26-376af58a56f6
DOI: 10.1101/2025.01.30.635767

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