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Article

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

31 May 2019

Abstract excerpt

Chaperone-mediated autophagy (CMA) contributes to the lysosomal degradation of a selective subset of proteins. Selectivity lies in the chaperone heat shock cognate 71 kDa protein (HSC70) recognizing a pentapeptide motif (KFERQ-like motif) in the protein sequence essential for subsequent targeting and degradation of CMA substrates in lysosomes. Interest in CMA is growing due to its recently identified regulatory...

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PMID: 31150375
DOI: 10.1371/journal.pbio.3000301

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