Article

TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain

2018-05-09

Abstract excerpt

TMEM106B was initially identified as a risk factor for FTLD, but recent studies highlighted its general role in neurodegenerative diseases. Very recently TMEM106B has also been characterized to regulate aging phenotypes. TMEM106B is a 274-residue lysosomal protein whose cytoplasmic domain functions in the endosomal/autophagy pathway by dynamically and transiently interacting with diverse categories of proteins but...

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Literature Corpus work: d0685d17-0b02-578e-8a6c-0e0b5d8867be
DOI: 10.1101/317958

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