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Article

Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70.

Nature structural & molecular biology - 1 Jan 2018

Gowda Naveen K C, Kaimal Jayasankar M, Kityk Roman, Daniel Chammiran, Liebau Jobst, Öhman Marie, Mayer Matthias P, Andréasson Claes

Abstract excerpt

Protein quality control depends on the tight regulation of interactions between molecular chaperones and polypeptide substrates. Substrate release from the chaperone Hsp70 is triggered by nucleotide-exchange factors (NEFs) that control folding and degradation fates via poorly understood mechanisms. We found that the armadillo-type NEFs budding yeast Fes1 and its human homolog HspBP1 employ flexible N-terminal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29323280
DOI: 10.1038/s41594-017-0008-2

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