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Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR

6 Mar 2020

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel cause cystic fibrosis. Chaperones, including HSC70, DNAJA1 and DNAJA2, play key roles in both the folding and degradation of wild-type and mutant CFTR at multiple cellular locations. DNAJA1 and HSC70 promote the folding of newly synthesized CFTR at the endoplasmic reticulum (ER), but are required for the rapid turnover of...

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PMID: 32144307
DOI: 10.1038/s41598-020-61107-x

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