Article

Tuning the Hsp70 Chaperone Cycle: Emerging Roles of GrpE-Like NEFs in Proteostasis and Organelle Function

2025-08-29

Abstract excerpt

The heat shock protein 70 (Hsp70) family of molecular chaperones is essential for nearly every cell to support protein homeostasis through folding, signaling, and quality control. Hsp70 functionality critically depends on co-chaperones, including the GrpE-like family of nucleotide exchange factors (NEFs), first identified in Escherichia coli as GrpE. These factors have long been recognized for their ability to cat...

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Literature Corpus work: cc14aeb1-08fe-5fcd-917c-5e186ed49638
DOI: 10.20944/preprints202508.2168.v1

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