Article

Liver CYP4A autophagic-lysosomal degradation (ALD): A major role for the autophagic receptor SQSTM1/p62 through an uncommon target interaction site

2024-10-14

Abstract excerpt

<h4>ABSTRACT</h4> The hepatic P450 hemoproteins CYPs 4A are typical N-terminally anchored Type I endoplasmic reticulum (ER)-proteins, that are inducible by hypolipidemic drugs and other “peroxisome proliferators”. They are engaged in the ω-/ω-1-oxidation of various fatty acids including arachidonic acid, prostaglandins and leukotrienes and in the biotransformation of some therapeutic drugs. Herein we report that...

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Literature Corpus work: 091b53eb-fb43-5e3e-b05b-d10f4699c8bf
DOI: 10.1101/2024.10.14.618315

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