Article

A sexually dimorphic hepatic cycle of periportal VLDL generation and subsequent pericentral VLDLR-mediated lipoprotein re-uptake

2023-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Recent single-cell transcriptomes revealed spatiotemporal programmes of liver function on the sublobular scale. However, how sexual dimorphism affected this space-time logic remained poorly understood. We addressed this by performing scRNA-seq in the mouse liver, which revealed that sex, space and time together markedly influence xenobiotic detoxification and lipoprotein metabolism. The very low...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 012e6961-06ec-5cf8-b1c6-5f032e23ecbc
DOI: 10.1101/2023.10.07.561324

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A sexually dimorphic hepatic cycle of periportal VLDL generation and subsequent pericentral VLDLR-mediated lipoprotein re-uptakeDOI 10.1101/2023.10.07.561324Read

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insultSemantic proximity Read

Temporal Analyses of Postnatal Liver Development and Maturation by Single Cell TranscriptomicsSemantic proximity Read

Early-Life Environmental Exposures Reprogram Epigenomic Aging to Alter Gene Expression TrajectoriesSemantic proximity Read

Chronic Disruption of the Late Cholesterol Synthesis Leads to Female-Prevalent Liver CancerSemantic proximity Read

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion <i>in vitro</i> and in mouse liverSemantic proximity Read

A comparative analysis of liver transcriptome suggests divergent liver function among human, mouse and ratSemantic proximity Read

Sex-dependent pathways in hepatocarcinogenesis triggered by deregulated cholesterol synthesisSemantic proximity Read

Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatmentSemantic proximity Read

Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 VectorsSemantic proximity Read

Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosisSemantic proximity Read

Plasticity of Epigenomic and Transcriptomic Aging Reveals Common Targets for Reprogramming by Environmental ExposuresSemantic proximity Read

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and femalesSemantic proximity Read