Article

ORP2 regulates free cholesterol accumulation in hepatocytes during MASH

2025-01-04

Abstract excerpt

<h4>Background</h4> Cholesterol crystals in hepatocytes are known to strongly associate with human Metabolic Dysfunction-Associated Steatohepatitis (MASH). However, it remains unclear which molecular pathway(s) regulates free cholesterol accumulation, and therefore the formation of cholesterol crystals in hepatocytes. In cultured cell lines, oxysterol-binding protein-related protein 2 (ORP2) functions to deliver...

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Literature Corpus work: 3cc13d01-3f18-566a-a82c-126a68040284
DOI: 10.1101/2025.01.03.631227

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