Overlapping yet Distinct Functions of VMP1 and TMEM41B in Modulating Hepatic Lipoprotein Secretion and Autophagy

Abstract excerpt

<h4>Background</h4> Transmembrane protein 41B (TMEM41B) and vacuolar membrane protein 1 (VMP1) are endoplasmic reticulum (ER) scramblases that shuttle phospholipids between the inner and outer leaflets of the ER membrane. Both TMEM41B and VMP1 also play critical roles in regulating hepatic lipoprotein secretion and autophagy. Despite these similarities, whether TMEM41B and VMP1 exhibit different roles in very low...

Topics

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• Autophagy in Disease and Therapy
• Fatty Liver
• Hepatocytes
• interferon and immune responses
• Lipid Droplets
• Lipid metabolism and biosynthesis
• Liver Disease Diagnosis and Treatment
• Mosquito-borne diseases and control

Identifiers and source

Literature Corpus work

4db468d7-cb18-5523-8c7e-be5dc57f1a7a

DOI

10.1101/2025.04.07.647617