Article

Translation Inhibition by Rocaglamide A Enhances Susceptibility of Yeasts to Caspofungin

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Fks1 catalyzes the synthesis of β-1,3-glucans, a major structural component of the fungal cell wall, and is the primary target of the antifungal drug caspofungin. Mutations in Fks1 confer caspofungin resistance by disrupting its interaction with the drug, thereby reducing inhibition of Fks1 enzymatic activity. Previous studies demonstrated that translation of the FKS1 mRNA was highly dependent...

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Literature Corpus work: 08c99546-5106-5ad8-ad72-f938907f23b9
DOI: 10.1101/2025.09.21.677667

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