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Rapamycin and caspofungin show synergistic antifungal effects in caspofungin-susceptible and caspofungin-resistant <i>Candida</i> strains <i>in vitro</i>

2023-10-05

Abstract excerpt

<h4>Objectives</h4> Caspofungin is an echinocandin antifungal agent that inhibits synthesis of glucan required for the fungal cell wall. Resistance is mediated by mutation of Fks1 glucan synthase, among which S645P is the most common resistance-associated polymorphism. Rapamycin is a macrolide that inhibits the mechanistic target of rapamycin (mTOR) protein kinase activity. This study investigated the interaction...

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Literature Corpus work
50b09867-7b83-58e7-b3b8-56642321c99b
DOI
10.1101/2023.10.05.560425
Open publication

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Rapamycin and caspofungin show synergistic antifungal effects in caspofungin-susceptible and caspofungin-resistant <i>Candida</i> strains <i>in vitro</i>DOI 10.1101/2023.10.05.560425
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