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Article

A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols.

The EMBO journal - 15 Nov 2001

Ashe M P, Slaven J W, De Long S K, Ibrahimo S, Sachs A B

Abstract excerpt

Fusel alcohols are natural products of amino acid catabolism in the yeast Saccharomyces cerevisiae that cause morphological changes similar to those seen during pseudohyphal growth. We have discovered that certain of these alcohols, including butanol and isoamyl alcohol, bring about a rapid inhibition of translation at the initiation step. This inhibition is strain specific and is not explained by previously...

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Identifiers

PMID: 11707417
DOI: 10.1093/emboj/20.22.6464
PMCID: PMC125737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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