Article

Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity

2019-04-11

Abstract excerpt

<h4>ABSTRACT</h4> The disruption of protein folding homeostasis in the endoplasmic reticulum (ER) results in an accumulation of toxic misfolded proteins and activates a network of signaling events collectively known as the unfolded protein response (UPR). While UPR activation upon ER stress is well characterized, how other signaling pathways integrate into the ER proteostasis network is unclear. Here, we sought t...

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Literature Corpus work: 37553df7-5529-5af5-8095-ec719ce271f1
DOI: 10.1101/605824

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