Article
Ribosomal P-protein stalk function is targeted by sordarin antifungals.
The Journal of biological chemistry - 25 Sept 1998
Gómez-Lorenzo M G, García-Bustos J F
Abstract excerpt
Sordarin derivatives are remarkably selective inhibitors of fungal protein synthesis. Available evidence points to a binding site for these inhibitors on elongation factor 2, but high affinity binding requires the presence of ribosomes. The gene mutated in one of the two isolated complementation...
Topics
- Amino Acid Sequence
- Animals
- Antifungal Agents
- Genetic Complementation Test
- Humans
- Indenes
- Molecular Sequence Data
- Mutation
- Peptide Elongation Factor 2
- Peptide Elongation Factors
- Protozoan Proteins
- Ribosomal Proteins
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid