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Article

Ribosomal P-protein stalk function is targeted by sordarin antifungals.

The Journal of biological chemistry - 25 Sept 1998

Gómez-Lorenzo M G, García-Bustos J F

Abstract excerpt

Sordarin derivatives are remarkably selective inhibitors of fungal protein synthesis. Available evidence points to a binding site for these inhibitors on elongation factor 2, but high affinity binding requires the presence of ribosomes. The gene mutated in one of the two isolated complementation groups of Saccharomyces cerevisiae mutants resistant to the sordarin derivative GM193663 has now been identified. It is...

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PMID: 9737960
DOI: 10.1074/jbc.273.39.25041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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