Article
TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.
The Journal of biological chemistry - 17 Nov 1995
Lorenz M C, Heitman J
Abstract excerpt
The antifungal, immunosuppressive compound rapamycin arrests the cell cycle in G1 in both yeast cells and T-lymphocytes. Previous genetic studies in yeast identified mutations in three genes, FPR1 (FKBP12), TOR1, and TOR2, which confer rapamycin resistance, and genetic findings implicated the TOR...
Topics
- Alleles
- Antifungal Agents
- Base Sequence
- Carrier Proteins
- Cell Cycle Proteins
- DNA Primers
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Fungal Proteins
- Genes, Fungal
- Heat-Shock Proteins
- Kinetics
- Molecular Sequence Data
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Polyenes
- Polymerase Chain Reaction
- Protein Binding