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Article

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

The Journal of biological chemistry - 17 Nov 1995

Lorenz M C, Heitman J

Abstract excerpt

The antifungal, immunosuppressive compound rapamycin arrests the cell cycle in G1 in both yeast cells and T-lymphocytes. Previous genetic studies in yeast identified mutations in three genes, FPR1 (FKBP12), TOR1, and TOR2, which confer rapamycin resistance, and genetic findings implicated the TOR proteins as direct targets of FKBP12-rapamycin. Consistent with this model, we find that modulating TOR1 and TOR2...

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Source

Identifiers

PMID: 7499212
DOI: 10.1074/jbc.270.46.27531

Genes

FPR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.PMID 7499212Read ↗

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Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.Semantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

Missense mutations at the FKBP12-rapamycin-binding site of TOR1.Semantic proximity Read ↗

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiaeSemantic proximity Read ↗

FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae.Semantic proximity Read ↗

The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain.Semantic proximity Read ↗

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.Semantic proximity Read ↗

Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p.Semantic proximity Read ↗

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.Semantic proximity Read ↗

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.Semantic proximity Read ↗

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs.Semantic proximity Read ↗

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