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Article

Translation initiation factor 4A from Saccharomyces cerevisiae: analysis of residues conserved in the D-E-A-D family of RNA helicases.

Molecular and cellular biology - 1 Jul 1991

Schmid S R, Linder P

Abstract excerpt

The eukaryotic translation initiation factor 4A (eIF-4A) possesses an in vitro helicase activity that allows the unwinding of double-stranded RNA. This activity is dependent on ATP hydrolysis and the presence of another translation initiation factor, eIF-4B. These two initiation factors are thought to unwind mRNA secondary structures in preparation for ribosome binding and initiation of translation. To further...

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Identifiers

PMID: 2046664
DOI: 10.1128/mcb.11.7.3463-3471.1991
PMCID: PMC361078

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