Article
Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3.
The Journal of biological chemistry - 28 Feb 2003
Anand Monika, Chakraburtty Kalpana, Marton Matthew J, Hinnebusch Alan G, Kinzy Terri Goss
Abstract excerpt
The translation elongation machinery in fungi differs from other eukaryotes in its dependence upon eukaryotic elongation factor 3 (eEF3). eEF3 is essential in vivo and required for each cycle of the translation elongation process in vitro. Models predict eEF3 affects the delivery of cognate aminoacyl-tRNA, a function performed by eEF1A, by removing deacylated tRNA from the ribosomal Exit site. To dissect eEF3...
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