Article
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
Molecular cell - 4 Aug 2016
Srivas Rohith, Shen John Paul, Yang Chih Cheng, Sun Su Ming, Li Jianfeng, Gross Andrew M, Jensen James, Licon Katherine, Bojorquez-Gomez Ana, Klepper Kristin, Huang Justin, Pekin Daniel, Xu Jia L, Yeerna Huwate, Sivaganesh Vignesh, Kollenstart Leonie, van Attikum Haico, Aza-Blanc Pedro, Sobol Robert W, Ideker Trey
Abstract excerpt
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and genes...
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