Article

Mapping the human kinome in response to DNA damage

2018-08-06

Abstract excerpt

<h4>Summary</h4> We provide a catalog for the effects of the human kinome on cell survival in response to DNA damaging agents, selected to cover all major DNA repair pathways. By treating 313 kinase-deficient cell lines with ten diverse DNA damaging agents, including seven commonly used chemotherapeutics, we were able to identify kinase specific vulnerabilities and resistances. In order to identify novel syntheti...

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Literature Corpus work: 8a2c534c-e81a-519b-b8c9-ef09de55e2d9
DOI: 10.1101/385344

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