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Article

Using human genetics to understand the disease impacts of testosterone in men and women.

Nature medicine - 1 Feb 2020

Ruth Katherine S, Day Felix R, Tyrrell Jessica, Thompson Deborah J, Wood Andrew R, Mahajan Anubha, Beaumont Robin N, Wittemans Laura, Martin Susan, Busch Alexander S, Erzurumluoglu A Mesut, Hollis Benjamin, O'Mara Tracy A, McCarthy Mark I, Langenberg Claudia, Easton Douglas F, Wareham Nicholas J, Burgess Stephen, Murray Anna, Ong Ken K, Frayling Timothy M, Perry John R B

Abstract excerpt

Testosterone supplementation is commonly used for its effects on sexual function, bone health and body composition, yet its effects on disease outcomes are unknown. To better understand this, we identified genetic determinants of testosterone levels and related sex hormone traits in 425,097 UK Biobank study participants. Using 2,571 genome-wide significant associations, we demonstrate that the genetic...

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Identifiers

PMID: 32042192
DOI: 10.1038/s41591-020-0751-5
PMCID: PMC7025895

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