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Article

From genetic causality to druggable targets: A multiomics framework identifies ZSCAN16 in gout pathogenesis.

Science progress - 1 Jan 2025

Chen Chuanliang, Zheng Xifan, Li Zeming, Wang Hongtao, Yao Jun

Abstract excerpt

ObjectiveGout is a prevalent form of inflammatory arthritis in which many patients respond suboptimally to current therapies. Drug development is hampered by a lack of genetically validated targets, leading to high clinical trial attrition. This study aimed to systematically identify and prioritize novel, druggable targets for gout via a multilayered genetic and functional genomics approach.MethodsWe performed...

Read the complete abstract on PubMed

Topics

Humans
Gout
Genome-Wide Association Study
Quantitative Trait Loci
Molecular Docking Simulation
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcription Factors

Genetic Predisposition to Disease

Genomics

Polymorphism, Single Nucleotide

Multiomics

Source

Open in PubMed Open full text

Identifiers

PMID: 41369912
DOI: 10.1177/00368504251407179
PMCID: PMC12696314

Genes

ZSCAN16
TRIM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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