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Article

Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study.

Hereditas - 30 Dec 2024

Fan Mingyuan, Yun Zhangjun, Yuan Jiushu, Zhang Sai, Xie Hongyan, Lu Dingyi, Yuan Haipo, Gao Hong

Abstract excerpt

BACKGROUND: Considering that the treatment of gout is poor, we performed a Mendelian randomization (MR) study to identify candidate biomarkers and therapeutic targets for gout. METHODS: A drug-targeted MR study was performed for gout by integrating the gout genome-wide association studies (GWAS) summary data and cis expression quantitative trait loci of 2,633 druggable genes from multiple cohorts. Summary...

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Identifiers

PMID: 39734218
DOI: 10.1186/s41065-024-00362-8
PMCID: PMC11684267

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