Article

Germline-encoded V(D)J gene usage does not impose strict constraints on the epitope-specificity of T cell receptors

2026-08-20

Abstract excerpt

The theoretical diversity of T cell receptors (TCRs), generated through V(D)J recombination, is enormous, yet the diversity of TCRs capable of recognizing the same epitope remains unknown. Defining this TCR solution space is essential for uncovering basic principles that govern TCR specificity. Using single-cell RNA and TCR sequencing, we generated ultra-deep (more than 4000 unique TCRs per epitope) epitope-specif...

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Literature Corpus work: ac0a9c45-6b06-5c31-84be-57c37116b92c
DOI: 10.64898/2026.08.20.745957

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