Article

Optimisation of T cell receptors using in vivo recombination and selection

2016-01-01

Abstract excerpt

The αβT cell receptor (TCR) orchestrates immunity through the recognition of peptides, derived from degraded proteins, presented on major histocompatibility complex (MHC) molecules. The remarkable ability of the receptor to respond to a vast plethora of antigens is driven by V(D)J recombination, a process which generates a highly diverse TCR repertoire by somatic gene rearrangement of coding DNA. TCR diversity is...

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Identifiers and source

Literature Corpus work: f881c95d-7520-53c1-a3f3-c36b0586ca63
DOI: 10.25560/33347

Open publication

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