Article

Microtubule deacetylation drives kinesin-1 mediated mitochondrial transport accelerating breast cancer cell migration

2025-10-30

Abstract excerpt

Mitochondrial trafficking is reprogrammed in metastatic breast cancer cells to sustain their migratory and invasive behavior. Mitochondria repositioning to sites of high energy demand is governed by a balance between opposing dynein and kinesin-1 (KIF5B) molecular motors whose regulation remains incompletely understood. Here, we identify the SYBU gene as a candidate prognostic marker downregulated in metastatic d...

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Identifiers and source

Literature Corpus work: 08785680-149c-552b-9b3f-a8770a567cd6
DOI: 10.1101/2025.10.29.685374

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