Article

The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5α

2020-02-28

Abstract excerpt

<h4>ABSTRACT</h4> Invadopodia are actin-based proteolytic membrane protrusions required for invasive behavior and tumor growth. We used our high-content screening assay to identify kinases impacting invadopodia formation. Among the top hits we selected TAO3, a STE20-like kinase of the GCK subfamily, for further analysis. TAO3 was over-expressed in many human cancers, and regulated invadopodia formation in melanom...

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Literature Corpus work: 4d7ff59d-3e63-517d-af84-be75f8a12e30
DOI: 10.1101/2020.02.27.968305

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The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5αDOI 10.1101/2020.02.27.968305Read

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