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Filopodia-mediated basement membrane assembly at pre-invasive tumor boundaries

2021-10-22

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer, where the tumor is encapsulated by a basement membrane (BM). At the invasive phase, the BM barrier is compromised enabling tumor cells to escape into the surrounding stroma. The molecular mechanisms that establish and maintain an epithelial BM barrier in vivo are poorly understood. Myosin-X (MYO10) is a filopodia-inducing motor protein impli...

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Literature Corpus work
08fdb311-900d-581d-9b6b-4cf739cd3b7b
DOI
10.1101/2021.10.22.464987
Open publication

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Filopodia-mediated basement membrane assembly at pre-invasive tumor boundariesDOI 10.1101/2021.10.22.464987
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