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Article

DPYSL2 interacts with JAK1 to mediate breast cancer cell migration

9 Apr 2022

Abstract excerpt

The intricate neuronal wiring during development requires cytoskeletal reorganization orchestrated by signaling cues. Because cytoskeletal remodeling is a hallmark of cell migration, we investigated whether metastatic cancer cells exploit axon guidance proteins to migrate. Indeed, in breast cancer patients, we found a significant correlation between mesenchymal markers and the expression of...

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PMID: 35575798
DOI: 10.1083/jcb.202106078

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