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MYO10-filopodia support basement membranes at pre-invasive tumor boundaries

1 Oct 2022

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer. During invasion, the encapsulating DCIS basement membrane (BM) is compromised, and tumor cells invade the surrounding stroma. The mechanisms that regulate functional epithelial BMs in vivo are poorly understood. Myosin-X (MYO10) is a filopodia-inducing protein associated with metastasis and poor clinical outcome in invasive breast cancer...

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PMID: 36283390
DOI: 10.1016/j.devcel.2022.09.016

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