Article

Protein-state dysregulation and sex-specific neurodevelopmental signatures in schizophrenia forebrain organoids

2026-06-03

Abstract excerpt

Schizophrenia is highly heritable, yet the molecular mechanisms linking genetic risk to abnormal human brain development remain poorly understood. To address this, we generated dorsal forebrain organoids from 17 individuals with idiopathic schizophrenia and 17 age- and sex-matched controls and profiled them across multiple molecular layers, including single-nucleus transcriptomics, quantitative proteomics, metabol...

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Literature Corpus work: c4fcedea-d4b6-5c03-9f16-363a39c45a0d
DOI: 10.64898/2026.06.01.729221

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