Article
Age-related clonal haemopoiesis is associated with increased epigenetic age
2019-04-07
Abstract excerpt
Age-related clonal haemopoiesis (ARCH) in healthy individuals was initially observed through an increased skewing in X chromosome inactivation. More recently, several groups reported that ARCH is driven by somatic mutations. The most prevalent ARCH mutations are in the DNMT3A and TET2 genes, previously described as drivers of myeloid malignancies. ARCH is associated with an increased risk for haematological cancer...
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Identifiers and source
- Literature Corpus work
- c4c949cb-2bbf-5ca2-b089-754f91f6dc8f
- DOI
- 10.1101/600759