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Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' offspring. Is there a role for allelic imbalance in healthy aging and longevity?

Aging cell - 1 Apr 2012

Gentilini Davide, Castaldi Davide, Mari Daniela, Monti Daniela, Franceschi Claudio, Di Blasio Anna Maria, Vitale Giovanni

Abstract excerpt

Recently, it has been proposed that age-related X chromosome inactivation (XCI) skewing can clinically result in late-onset X-linked disorders. This observation leads to hypothesize that age-related skewed XCI might also influence lifespan in women. To investigate this issue, we employed a new experimental model of longevity and healthy aging including 55 female centenarians, 40 of their offspring, 33 age-matched...

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Identifiers

PMID: 22292741
DOI: 10.1111/j.1474-9726.2012.00790.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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