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Allelic effects on<i>KLHL17</i>expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33

2024-09-16

Abstract excerpt

Pancreatic Ductal Adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the U.S. Both rare and common germline variants contribute to PDAC risk. Here, we fine-map and functionally characterize a common PDAC risk signal at 1p36.33 (tagged by rs13303010) identified through a genome wide association study (GWAS). One of the fine-mapped SNPs, rs13303160 (r 2 =0.93 in 1000G EUR samples, OR=1.23,...

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Identifiers and source

Literature Corpus work
082321d6-2751-5b42-a30a-69c222672a7e
DOI
10.1101/2024.09.16.24313748
Open publication

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Allelic effects on<i>KLHL17</i>expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33DOI 10.1101/2024.09.16.24313748
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