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Article

Whole genome sequencing identifies rare germline variants enriched in cancer related genes in first degree relatives of familial pancreatic cancer patients.

Clinical genetics - 1 Nov 2021

Tan Ming, Brusgaard Klaus, Gerdes Anne-Marie, Mortensen Michael Bau, Detlefsen Sönke, Schaffalitzky de Muckadell Ove B, Joergensen Maiken Thyregod

Abstract excerpt

First-degree relatives (FDRs) of familial pancreatic cancer (FPC) patients have increased risk of developing pancreatic ductal adenocarcinoma (PDAC). Investigating and understanding the genetic basis for PDAC susceptibility in FPC predisposed families may contribute toward future risk-assessment and management of high-risk individuals. Using a Danish cohort of 27 FPC families, we performed whole-genome sequencing...

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PMID: 34313325
DOI: 10.1111/cge.14038
PMCID: PMC9291090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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