Article
Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk.
Human genomics - 2 Feb 2024
Ünal Pelin, Lu Ye, Bueno-de-Mesquita Bas, van Eijck Casper H J, Talar-Wojnarowska Renata, Szentesi Andrea, Gazouli Maria, Kreivenaite Edita, Tavano Francesca, Małecka-Wojciesko Ewa, Erőss Bálint, Oliverius Martin, Bunduc Stefania, Nóbrega Aoki Mateus, Vodickova Ludmila, Boggi Ugo, Giaccherini Matteo, Kondrackiene Jurate, Chammas Roger, Palmieri Orazio, Theodoropoulos George E, Bijlsma Maarten F, Basso Daniela, Mohelnikova-Duchonova Beatrice, Soucek Pavel, Izbicki Jakob R, Kiudelis Vytautas, Vanella Giuseppe, Arcidiacono Paolo Giorgio, Włodarczyk Barbara, Hackert Thilo, Schöttker Ben, Uzunoglu Faik G, Bambi Franco, Goetz Mara, Hlavac Viktor, Brenner Hermann, Perri Francesco, Carrara Silvia, Landi Stefano, Hegyi Péter, Dijk Frederike, Maiello Evaristo, Capretti Giovanni, Testoni Sabrina Gloria Giulia, Petrone Maria Chiara, Stocker Hannah, Ermini Stefano, Archibugi Livia, Gentiluomo Manuel, Cavestro Giulia Martina, Pezzilli Raffaele, Di Franco Gregorio, Milanetto Anna Caterina, Sperti Cosimo, Neoptolemos John P, Morelli Luca, Vokacova Klara, Pasquali Claudio, Lawlor Rita T, Bazzocchi Francesca, Kupcinskas Juozas, Capurso Gabriele, Campa Daniele, Canzian Federico
Abstract excerpt
Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify...
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