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Article

Risk SNP in a transcript of RP11-638I2.4 increases lncRNA-YY1 interaction and pancreatic cancer susceptibility.

Archives of toxicology - 1 Oct 2023

Zhang Ming, Li Yanmin, Zhang Fuwei, Geng Hui, Cai Yimin, Lu Zequn, Li Bin, Ning Caibo, Wang Wenzhuo, Li Haijie, Tian Jianbo, Zhu Ying, Miao Xiaoping

Abstract excerpt

Tens of thousands of long non-coding RNAs (lncRNAs) have been identified through RNA-seq analysis, but the biological and pathological significance remains unclear. By integrating the genome-wide lncRNA data with a cross-ancestry meta-analysis of PDAC GWASs, we depicted a comprehensive atlas of pancreatic ductal adenocarcinoma (PDAC)-associated lncRNAs, containing 1,204 lncRNA (445 novel lncRNAs and 759 GENCODE...

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PMID: 37587385
DOI: 10.1007/s00204-023-03564-7

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